Class Notes

B Cell Development and Function

Dr. M. Shimoda
Mechanisms of Disease, Lecture 5a
January 24th, 2006

  1. B Cell Development and Function
  2. B Cells
  3. Antibody Functions
  4. B-Cell Development and Differentiation

B Cells

Antibody Functions

B-Cell Development and Differentiation

  1. Generation of B-cell receptors in bone marrow: B cell precursor rearranges its immunoglobulin genes (somatic recombination) and develops its specificity.
  2. Negative selection in bone marrow: Immature B cell bound to self cell-surface antigen is removed from the repertoire.
  3. B cells migrate to the peripheral lymphoid organs: Mature B cell bound to foreign antigen is activated.
  4. Antibody secretion and memory cells in bone marrow and lymphoid tissue: Activated B cells give rise to both plasma and memory cells.
  5. Early B-cell development is dependent on binding to bone-marrow stromal cells.
  6. Steps of rearrangement signal steps of B-cell development, ensuring that failed recombinants do not mature.
  7. Helper T cells stimulate the proliferation and then differentiation of B cells that recognize the same antigen.
    • They also provide cytokines which promote isotype-switching.
    • Germinal centers of lymph nodes are the site for both isotype-switching and for somatic mutations which alter B-cell specificity and affinity for its antigen.

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